Posted by undopaminergic on May 17, 2008, at 18:42:36
In reply to Re: Michael: did Buprenorphine work well ? (n/m), posted by garylee on May 16, 2008, at 19:38:40
> > Can I ask you what was the effect of Buprenorphine on you and your social phobia ? I'm amazed if it really help even mildly because it would support 'Michael Bell' hypothesis about social phobic having too much CCK activity/concentration ... If that's the case we need to collect a couple 'anecdoctal cases' from people like you and Michael and report that to the scientific community ASAP.
> > /\/\arty
> Hi Marty
> Can't really explain the loss of the SP because the Buprenorphine pretty much put me into remission. I was still taking my other meds, and my sleepers but I was taking 2mg under the tounge at night and sleeping well. I was able to get up for work at 7:30 no problem and was getting worker of the week etc at work, it was great!
> Sadly after about 3 1/2 weeks it started to poop out, also I couldn't take the constipation anymore, hadn't been to the toilet for over a week, it was like carrying bricks! lol
> I want to try a stronger opiate now, have found a source for Hydrocodone, just getting the money together to order it, so we'll see...
For two days, I've experimented with codeine-based cough syrup in an attempt to lessen my cough, but incidentally, I've noticed that I feel remarkably relaxed and free from all worry and discomfort. I'm certain that in people responding to codeine (or other opiates) as I do, it would be a highly effective treatment for social phobia/anxiety, and quite probably other anxiety disorders, at least in the short term.
Tolerance often develops to many of the effects of opioids. Unfortunately, constipation is one of the effects particularly resistant to tolerance, and in long-term use of opiates, it often requires treatment with laxative agents. The extent to which tolerance develops to the anxiolytic effects is an interesting question, an answer to which is essential for longer term use of these agents for SP or other anxiety disorders. If it is an issue, memantine could be a possible remedy - it does prevent loss of the analgesic effects of morphine, and might help preserve anxiolytic efficacy also.