Posted by Larry Hoover on October 15, 2004, at 10:58:36
In reply to Re: Cured my depression and anxiety by mistake??!!, posted by DynaUnity333 on October 15, 2004, at 7:54:51
> Cheers for that Larry,
>
> Having done a bit of a search around the internet i would have to concur that you are prefectly correct, what a shame.Oh, I agree. It is a shame. Tramadol has a very beneficial effect on my mood, but only if used occasionally. I've had to take e.g. oxycodone for joint surgery, and I have had the most serious sort of mood crash after withdrawing from it. It seems that there was an underlying mood effect that lead to compensatory changes in brain function, but the withdrawal of the opiate left me totally "unsupported", and down I went.
> Seems to me that if someone could invent a medication that prevented tolerance to opiates that depression and anxiety disorders akin to mine would be a thing of the past, but i still think that the powers that be, Big Brother and all that, would much rather have us sedtade than depression free anyway. Maybe thats why there is such little research done on novel ideas. (Except the French, wonder why that is???)
It's being looked at, but we don't have a key piece of the puzzle. For pain management, dextromethorphan (and other NMDA-active drugs) can abolish the tolerance effect. A combination drug, called Morphidex (morphine and dextromethorpah), or something like that, is in trials.
The recognition of pain sensation (nociception) involves a different type of opiate receptor than the one that influences mood. We don't yet know how to block tolerance at that other receptor class.> Anyway, buprenorphine looks like the best bet if i was to go such a way but asking a GP in the UK to try something like that would be like asking Bush to comment on the home truths in the franheit 9/11 documentary. I would be laughed at and told to go away (in harsher words, you understand what im saying).
Oh, I get it. Still, it might be something to remember if and when a very serious depression takes hold of you.
Regards,
Lar
poster:Larry Hoover
thread:402639
URL: http://www.dr-bob.org/babble/20041012/msgs/403333.html