Posted by jrbecker on September 16, 2004, at 10:32:17
In reply to Re: GAD/Dysthymia/Smoking: Buspar (or Cymbalta or ...? » cache-monkey, posted by alesta on September 15, 2004, at 15:04:46
> > Also, in study published in the Journal of Neurochemistry, Prozac, Cymbalta and Buspar were administered to rats. When each was administered individually, this led to increases in dopamine (DA) and noradrenaline (NAD) for all three. >
>
> this study says that prozac *increases* dopamine! this contradicts everything i have read/know about ssris....it is pretty common knowledge that the SSRIs substantially *decrease* serotonin, which is why there is the anhedonia, sexual side effects, akathesia, etc., so i would not place any merit on what this study says, personally..
>
> i looked into this, and in basically all the sources i've seen, they say that Cymbalta is a dual reuptake inhibitor of the neurotransmitters serotonin and norepinephrine only..plus there tend to be sexual side effects eith the cymbalta, indicating a *lowering* of dopamine..so if there is some kind of slight dopamine agonist action in cymbalta, then it is counteracted by the serotonin agonist, so that there is no net increase of dopamine, probably...
>>
> good luck,
> amyby antagonizing the 5-HTC receptor, prozac (fluoxetine) does increase prefrontal DA.
cymbalta (duloxetine) does slightly increase DA as well since DA has a slight binding affinity with NE receptors.
poster:jrbecker
thread:390925
URL: http://www.dr-bob.org/babble/20040915/msgs/391479.html