Posted by alesta on September 15, 2004, at 15:04:46
In reply to Re: GAD/Dysthymia/Smoking: Buspar (or Cymbalta or ...? » alesta, posted by cache-monkey on September 15, 2004, at 13:39:25
> Well, according to the Cymbalta PI:
> "Preclinical studies have shown that duloxetine is a potent inhibitor of neuronal serotonin and norepinephrine reuptake and a less potent inhibitor of dopamine reuptake."
> So it seems basically like Wellbutrin mixed with an SSRI.
>
> Also, in study published in the Journal of Neurochemistry, Prozac, Cymbalta and Buspar were administered to rats. When each was administered individually, this led to increases in dopamine (DA) and noradrenaline (NAD) for all three. >this study says that prozac *increases* dopamine! this contradicts everything i have read/know about ssris....it is pretty common knowledge that the SSRIs substantially *decrease* serotonin, which is why there is the anhedonia, sexual side effects, akathesia, etc., so i would not place any merit on what this study says, personally..
i looked into this, and in basically all the sources i've seen, they say that Cymbalta is a dual reuptake inhibitor of the neurotransmitters serotonin and norepinephrine only..plus there tend to be sexual side effects eith the cymbalta, indicating a *lowering* of dopamine..so if there is some kind of slight dopamine agonist action in cymbalta, then it is counteracted by the serotonin agonist, so that there is no net increase of dopamine, probably...
hope something works for you..i'm not asking you to do anything drastic at all..do try the buspar at a higher dosage if you like..i was just giving you my thoughts and observations on each of these options, as you requested, and throwing some ideas out there for you, as well as are the others here...
good luck,
amy
poster:alesta
thread:390925
URL: http://www.dr-bob.org/babble/20040915/msgs/391151.html