Posted by 4WD on September 10, 2004, at 19:06:28
In reply to Re: does anyone feel good during the night...only » mike lynch, posted by KaraS on September 10, 2004, at 17:38:19
> I think that the genetic predisposition and less stressors are only part of the picture. It may also be physiological, having to do with the reuptake of neurotransmitters. Doesn't most of the reuptake happen when you are asleep? Then during the day, more of the neurotransmitters are made and so you have the most neurotransmitters available in the synapses at that time. This may be why if you stay up all night, you don't feel depressed (and in fact it can cause mania in some people). Some people routinely stay up at least one night a week as an antidepressant measure. I believe that Linkadge is doing that now.
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> -K
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>It's got to have something to do with cortisol levels and that whole HPA axis thing. Some of us have it one way and some the opposite but the shift seems to happen at about the same time for everybody - late afternoon or early evening. And that's the same time that cortisol levels change. I think they are supposed to slowly rise in the early morning to wake you up and are at their lowest at night. I can't remember if they peak or bottom out in late afternoon. But maybe different people's responses to high or low levels of cortisol is related to different people's responses to different classes of a/d drugs (why some people respond better to different neurotransmitter manipulation).
Marsha
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poster:4WD
thread:389021
URL: http://www.dr-bob.org/babble/20040909/msgs/389358.html