Posted by Dave001 on August 24, 2004, at 19:58:37
In reply to AME or somebody please help....again!!!!, posted by alesta on August 24, 2004, at 10:24:14
> hello.
>
> please look at this hyperlink:
>
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9365033
>
> so, great, ritalin is in the clear. but now i'm wondering about the amphetamines. does this study indicate that amphetamines are neurotoxic? or is this another study where they *injected* the rats with *super-high* doses in their brains? any help would be vastly appreciated. i feel this info could potentially help people.....I posted that abstract the other day. One thing the authors are saying here is that the release of dopamine alone isn't enough to explain the neuronal damage mediated by the amphetamines.
One thing to keep in mind about doses is that they can't be scaled directly (as a proportion of bodyweight) from one species to another. They first have to be adjusted for body surface area. According to the chart I have, when scaling the doses from mice to humans, you would first divide the dose by 12.3. You would divide by 7.4 for hamsters, 6.2 for rats, and 1.8 for dogs. These figures assume a 60 kg human. However, the formula I have that is supposed to be reasonably accurate for most scenarios is the following:
Human equivalent dose = animal dose in mg/kg x (animal weight in kg/human weight in kg) ^0.33*So when you see a dose of say, 10 mg/kg fed to rats, that would correspond to an approximate dose of 49 mg (gee, I think we can say 50) in a human of 60 kg or 132 lb.
* Since I can't use superscripts in text-only presentation, the ^ character is used to indicate exponentiation.
Dave
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poster:Dave001
thread:380741
URL: http://www.dr-bob.org/babble/20040821/msgs/381894.html