Posted by Shawn. T. on August 24, 2004, at 5:41:59
In reply to Re: are stimulants neurotoxic? thanks in --zeugma » alesta, posted by zeugma on August 23, 2004, at 18:41:06
Dopamine- induced neurotoxicity is primarily a result of the oxidation of free intracellular dopamine. Ritalin prevents dopamine reuptake, an effect that has been associated with a significant reduction in dopamine neurotoxicity. Less reuptake results in less intracellular dopamine. In addition, Ritalin increases vesicular dopamine uptake; this causes an even greater decrease in free intracellular dopamine. If these arguments aren't convincing enough, see the first article below; even multiple 120mg/kg doses of Ritalin weren't enough to produce a long-term depletion of striatal DA axonal markers in mice. I think that the author of the site had good intentions; he just didn't know what he was talking about in this instance.
Shawn
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9365033
poster:Shawn. T.
thread:380741
URL: http://www.dr-bob.org/babble/20040821/msgs/381622.html