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re: estrogen and anandamide

Posted by lil' jimi on August 22, 2004, at 5:02:07

In reply to re: anandamide deficiency Jasmineneroli, posted by lil' jimi on August 21, 2004, at 0:51:27


"In conclusion, the results reported here demonstrate that E2 activates the synthesis and inhibits the degradation of AEA in human endothelial cells, by acting at a surface receptor and causing a calcium-dependent release of NO. As a consequence, AEA is released in blood, where it can modulate the cardiovascular and immune systems. In particular, AEA released from estrogen-stimulated endothelial cells is capable of reducing the secretion of 5-HT from platelets. This newly found interplay between estrogen and AEA metabolism suggests that endocannabinoids might mediate some of the beneficial effects of estrogen, and seems to indicate a novel approach for the management of cardiovascular disease in postmenopausal women."




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