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Re: dopamine and downregulation

Posted by linkadge on August 17, 2004, at 17:50:47

In reply to Re: dopamine and downregulation » linkadge, posted by KaraS on August 17, 2004, at 15:41:46

Many people think that adding a dopimanergic to an SSRi will increase the effectivness. If you are apathetic and think it may be related to serotonin induced dopaminergic downregulation this can respond to a reduction in SSRI dose.

Here's what I think. I think the most common form of depressive illness is one with overactive catecholamines and underactive serotonin. This is why neuroleptics are often useful as AD adjunctives because they help lower excess dopamine.


Don't get me wrong, I do believe that stimulants and dopaminergics have a place in depression, but sometimes it is just as effective to lower the SSRi dose.

Linkadge


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