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Re: dopamine and downregulation » linkadge

Posted by KaraS on August 17, 2004, at 15:41:46

In reply to alesta, posted by linkadge on August 17, 2004, at 8:06:03

> My post was directed at nobody really. Just don't get trapped into the, I feel such and such so I need chemical such and such. For starters SSRi's don't depleat dopamine, they simply downregulate the system. This may be a good thing as some doctors have noted that there is little theraputic responce to SSRI's untill the dopaminergic/cholinergic system is downregulated. Believe it or not, my apathy and anhedonia responded to more SSRI at one point in my depression.
>
> Another thing to remember is that the dopamine downregulation generally happens slowly over the course of months. If you are feeling apathy and anhedonia in just the first few weeks of starting an SSRI, then you likely havn't responded to it fully as an antidepressant.
>
> I could be totally wrong, but I look back on my own experiences, and if I had just taken my medication as prescribed I probably would't be in the mess I am in now. I admit my tinkering around has done more dammage than the docotors have ever.
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> Linkadge
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"Downregulation of the system" may be a good thing but only to a point. After several months the SSRIs downregulated me to the point where I had absolutely no drive or motivation. I didn't even feel alive. I never want to feel that way again.

Kara


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poster:KaraS thread:378374
URL: http://www.dr-bob.org/babble/20040817/msgs/378796.html