Posted by SLS on August 17, 2004, at 8:27:35
In reply to Re: Dopaminergic Drug/Supp to Aug SSRI-Not Wellbutrin, posted by alesta on August 17, 2004, at 7:29:04
> no wonder we don't know the answer. no one else does, either!:)
I know. Somehow, I find this reassuring. If they did understand everything, AND STILL COULD NOT GET US WELL, we would be pretty much well doomed. It's that uncertainty that keeps hope alive for me.
> so, scott, you agree with panda that dopaminergic drugs are not the answer in the long run?
At this point in time, for the average sufferer of depression, I would say that I agree. Regulation of DA circuits might be one of the final pathways to remission, but it might be that it is those regulatory processes upstream that is necessary for long-term stable improvements. If you fine tune the inputs and interactions between the NE locus ceruleus and 5-HT raphe, perhaps you can re-regulate the activities of DA circuits in the mesolimbic cortex and watch depression disappear.
> did wellbutrin even work for you in the beginning?
No, not at all. I found nothing dopaminergic about it. But then again, a nosefull of cocaine did little for me when I experimented with it at my bachelor's party. It did do something positive, though. Or maybe it was the way the dancing girl... Never mind.
- Scott
poster:SLS
thread:378302
URL: http://www.dr-bob.org/babble/20040817/msgs/378565.html