Posted by SLS on August 16, 2004, at 15:17:03
In reply to Re: please be civil, posted by JLM on August 16, 2004, at 8:04:02
> The idea with a challenge/dechallenge/rechallenge
> is fairly simple: if give someone a drug once and you see a particular side effect, you can't really
> be sure of causation. But, if you give it to them AGAIN, and you see the same thing happen again, then you can be reasonably certain that it was indeed the drug. Especially if you give it to a healthy volunteer.
I don't think it is necessarily the point to prove that these drugs precipitate a suicidal state in an otherwise healthy individual. They might never do that. It might be that this happens only in those people who have a biological vulnerability for depression or perhaps only in those people whom express the depressive phenotype. In other words, the inability to get this thing to happen in a healthy volunteer doesn't preclude its happening in unhealthy individuals. Personally, I have been quite vocal in my belief that Prozac and other antidepressants produce suicidal states independent of any clinical antidepressant effect. I also don't believe that the appearance of akathisia is requisite for this to happen. Reboxetine, a selective NE reuptake inhibitor, made me suicidal in the absence of akathisia, but in the presence of anxiety, which Prozac and other SSRIs are well known to cause.
- Scott
poster:SLS
thread:208072
URL: http://www.dr-bob.org/babble/20040811/msgs/378309.html