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Re: this just in on atomoxetine » zeugma

Posted by SLS on August 8, 2004, at 10:20:39

In reply to this just in on atomoxetine » SLS, posted by zeugma on August 8, 2004, at 10:01:05

> I was the poster who brought up the atomoxetine-nortriptyline contrast. Atomoxetine's major metabobolite, 4-hydroxyatomoxetine, is a kappa-opiate partial agonist:

Hi Z.

It never ceases to amaze me how much biological activity these drugs and their metabolites have. On the one hand, it is upsetting to have to continually rework one's models and hypotheses to keep up with the overwhelming number discoveries made in neuroscience. On the other hand, it is settling to contemplate that the diverse and often unpredictable clinical effects of these drugs are that much closer to being elucidated. I wish I could keep up with all of it.

Thanks for posting this.

- Scott

 

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