Posted by linkadge on August 7, 2004, at 8:07:03
In reply to Re: some people just don't do well with norepinephrine » linkadge, posted by SLS on August 7, 2004, at 7:19:44
That sounds kind of fishy to me. If a drugs is a reputake inhibitor it works at the uptake sites equally. I don't know how it could not.
It is just like ritalin, the ADD effect is presumably by dopamine action in the frontal cortex, but it is certainly not selective to the frontal cortex. It can cause psychosis by lower brainstem activation as well.
I think that perhaps some of the *secondary properties* of the drug can control its actions. All TCAs have affinity for the 2a receptors, although for desipramine this is very small it could be involved in mood regulation.
I don't think there is anything wrong with using the drugs properties to predict a theraputic responce, the problem is that there are virtually no drugs for which we know all the properties :)
Linkadge
poster:linkadge
thread:374053
URL: http://www.dr-bob.org/babble/20040805/msgs/375008.html