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Re: Multiple Intolerances to Antidepressants Josh37

Posted by King Vultan on July 21, 2004, at 12:11:38

In reply to Re: Multiple Intolerances to Antidepressants, posted by Josh37 on July 21, 2004, at 10:20:34

> Todd--just wondering, how are the MAOI's working out for you? Are the dietary restrictions a pain in the ass? What are some other side effects?
> -Josh

The dietary restrictions are really not that annoying for me, but some of the actual side effects of the Nardil have been a problem. The insomnia was a big problem at first, but alternating between Halcion one night and Benadryl the next, plus using a sleep/relaxation CD, has pretty much cured that problem. The biggest continuing problem has been the lowering of heart rate and blood pressure, and I've come close to fainting several times. One plus is that I have borderline hypertension (140/90) and was able to dump my BP medication. Another common side effect of Nardil is delayed orgasm, but this is actually a plus in my case (and frankly one of the reasons I was interested in the drug). For the average person, however, for which this may be a problem, this can be extremely difficult to treat.

As for therapeutic effects, my opinion is that Nardil is an effective antidepressant and is very good in particular for social anxiety/social phobia. Unfortunately, it's becoming apparent my problem is rooted in anhedonia more than anything else, and this is why I'm thinking the Parnate, which is much more dopaminergic, might be a better choice. Parnate also has much fewer side effects in general compared to Nardil, and I believe it would likely be more tolerable and more effective than a dopamine agonist. However, the dopamine agonists are very easy to try compared to an MAOI, and as I said, I have considered it myself.





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