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Re: trimipramine and norepinephrine yeltom

Posted by Larry Hoover on July 20, 2004, at 19:45:19

In reply to trimipramine and norepinephrine Larry Hoover, posted by yeltom on July 20, 2004, at 18:14:48

> As I said, I read that abstract that said that trimipramine's antidepressant effects cannot be attributed to NE reuptake inhibition, but other sources say that it does affect NE. What's the truth? If it does affect NE, wouldn't the expectation be that it has energizing qualities in addtion to the sedating ones? Have you noticed any energizing effects?

It's such an old and generally disregarded med, that I've never found complete pharmacokinetic and binding affinity data. Most often, you'll just get some generic description of the effects of tricyclics. I haven't noticed any energizing effect. I take it and it makes me sleepy. But my dose is far below the therapeutic antidepressant dose.





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