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Re: Disappearance of chronic pain with Effexor? flipsactown

Posted by Sad Panda on July 8, 2004, at 4:27:09

In reply to Re: Disappearance of chronic pain with Effexor? Sad Panda, posted by flipsactown on July 8, 2004, at 0:24:56

> Hi Panda,
> I did try Amitriptyline for nearly 2 months, but gave it up in favor of Prozac because of weight gain and the fact that I was still depressed. In retrospect, I probably should have added Amitriptyline to augment Prozac.
> I have not tried Nortriptyline. I will keep it in mind should Lexapro fail. Another idea would be to ask my pdoc to Rx Nortriptyline or Amitriptyline to augment Lexapro. I probably will try this first before I try Effexor again because of my previous terrible experience with Effexor's SEs.
> Thanks for the advice.
> > Hi FST,
> >
> > Have you tried or considered Amitriptyline or Nortriptyline? I don't want to deter you from trying Effexor but these two have a pretty good track record for treating neuropathic(nerve damage?) pain.
> >
> > Cheers,
> > Panda.
> >


I am in the process of switching from Effexor + Remeron to Effexor + Nortriptyline. I'm trying to understand the P450 system since I don't think my pdoc spent too much time thinking about it when she gave me the script for Nortriptyline. Looks like Nort & Effexor raise each others levels somewhat, so I have to be carefull with the dosages. Prozac & Paxil look to be bad choice for combination with TCA's because they are inhibitors of CYP2D6 which is the enzyme that is responsible for the metabolism of a lot of drugs.





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