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Re: Disappearance of chronic pain with Effexor? King Vultan

Posted by Sad Panda on July 7, 2004, at 10:42:11

In reply to Re: Disappearance of chronic pain with Effexor? SLS, posted by King Vultan on July 7, 2004, at 7:32:33

> >
> >
> > I can't explain exactly why they work, but some antidepressants are effective treatments for chronic pain conditions. Some of the tricyclics, Effexor, and the soon to be approved Cymbalta are particularly noted. All of these drugs inhibit the reuptake of both norepinephrine and serotonin.
> >
> >
> > - Scott
> That has been my observation as well, that the ADs noted as being best for chronic pain tend to be the ones that block reuptake of both serotonin and norepinephrine. In particular, the tricyclics amitriptyline and nortriptyline come to mind, as these are widely used by GPs for treatment of chronic pain. Out of the 10 or so drugs I've tried, nortriptyline did happen to be the most effective one in suppressing my chronic headaches.
> Todd

Most likely nort's 5-HT2A antagonism. A fair few of the drugs used in migraine prevention are H1 & 5-HT2A antagonists such as methysergide, cyproheptadine, pizotifen & ofcourse amitrip.





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