Posted by rod on June 17, 2004, at 5:29:10
In reply to Re: Mechanism for Strattera CAUSING depression?, posted by Cairo on June 15, 2004, at 7:43:42
I definetly dont know, but one thing comes into my mind.
There are receptors called hetero-receptors which are noradrenergic receptors located on serotonergic nerve firbres (they also exist for other neurotransmitters), without noradrenergic nerve ending present. They seem to rely on the NE floating through our brain. When they get activated by NE, they "turn off" the serotonin nerve.
So, if a drug produces more NE to float around the brain, it "slows down" our Serotonin system. But this does not really explain why some NE reuptake inhibitors cause melancholia and some work against it. But I think this can be one possible explanation. And I am sure other, yet unkown pathways and/or even undiscovered neurotransmitters play a role in this.Roland
poster:rod
thread:353502
URL: http://www.dr-bob.org/babble/20040614/msgs/357476.html