Posted by zeugma on June 4, 2004, at 17:08:51
In reply to Re: Would strattera treat depression and ADD?? » zeugma, posted by Chairman_MAO on June 4, 2004, at 7:59:27
> You may have previously mentioned this, but have you ever given desipramine or Provigil a try? Another idea is to give some extra dopamine, perhaps with selegiline, which has some CNS alerting properties both intrinsically and via its metabolites. MAOIs, after all, deftly encourage insomnia. :)
I definitely need a stimulant of some sort, my caffeine intake is getting out of hand and when I don't guzzle it I collapse.
The desipramine idea is a good one, I had a BIG argument with my pdoc last visit about nortriptyline, desipramine, and Strattera, in which he claimed that Strattera was more efficacious for ADD than either of these TCA's. I protested that it certainly was more effective than nortriptyline, but that I had seen no evidence, none whatever, to indicate that it worked better than the imipramine metabolite. That was when he brought out the claim that these TCA's worked more in the brainstem, and Strattera worked in the frontal lobes, hence greater efficacy in ADD. No one here has been able to provide the least substantiation of this claim, and there are some knowledgeable people here. Neither has any diligent search of my own on this topic yielded anything, granted I am no neuroscientist and I don't have unlimited access to medline. I'm at an impasse. I strongly suspect Strattera of aggravating my already severe fatigue. I believe that TCA's are superior to anything produced in their wake. I think E.Lilly and Co. would dispute this :)
How is the desipramine working? Don't worry, I will respond to your formidable post on minds and brains soon :)
poster:zeugma
thread:353502
URL: http://www.dr-bob.org/babble/20040602/msgs/353852.html