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Re: Anorgasmia (-cyproheptadine for) Sad Panda

Posted by Questionmark on May 30, 2004, at 18:48:07

In reply to Re: Anorgasmia (-cyproheptadine for) Questionmark, posted by Sad Panda on May 30, 2004, at 3:47:41

> > > Periactin worked pretty well to alleviate this particular effect for me. It's a very old antihistimine, and is usually used for off label uses now -- like counteracting side effects from other medications. One of the best things about it is that you take it as needed, and it takes about 20 minutes to kick in.
> > >
> > > The potential downside, of course, is that it's an anti-histimine. Afterwards, you just roll over and go to sleep. (Sometimes this is a good thing, of course...)
> > >
> > > I can't say that it was perfect, but it really helped increase my ability to experience pleasure.
> > >
> > > Hope that helps.
> >
> >
> > Racer, thanks for your reply.
> > i have a prescription for Periactin (cyproheptadine) that i got a few months ago, but i have only used it a few times, and i don't exactly know how it affects me yet. From my few experiences with it, however, i thINk that the antihistamine effects are too much to benefit from it enough-- i just get too tired and blahhed out (i think). And the one time i took it i felt like crap for most of the next day (i.e., i had that antihistamine hangover that i always get w/ H1 blocking drugs, but i felt even more depressed than i usually do, too)-- which surprised me since i read that cyproheptadine only has a half-life of 4 hours. And because of how crappy i felt, i'm also wondering if the 5-HT2 antagonistic effects have a negative effect on me overall (besides the possible relief of anorgasmia). Oh and i didn't really get much relief from my anorgasmia with it at the doses i used.
> > i really need to experiment with it some more. Thank you for the post though. It gives me hope that it might actually work better than i realize so far, and it gives me more motivation to experiment with it some more again.
> >
>
> Cyproheptadine is a H1, 5-HT1 & 5-HT2A antagonist. 5-HT2A blockade relieves anorgasmia, 5-HT1 blockade temporarily stops the antidepressant effect SRI's & MAOI's give which hopefully will increase libido. If your libido is OK or not really a problem, then I would have a look for a 5-HT2A blocker that isn't a 5-HT1 blocker.
>
> Cheers,
> Panda.

Thanks Panda. But are you sure that cyproheptadine is a 5-HT1 antagonist? i've never seen/read that before. But that is a very helpful and important piece of information to me if it's true, so thank you if it is (& for responding, regardless). Also...

> > (i don't really have problems with this but on Nardil sometimes "it" is not quite as, um... "strong" as it could be-- i hope that makes sense).
> >
>
> Are you trying to say that it's like trying to stuff a marshmallow into a letterbox? :P

Hah, yes. (Good analogy).


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