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Re: Anorgasmia (-cyproheptadine for) Questionmark

Posted by Sad Panda on May 30, 2004, at 3:47:41

In reply to Re: Anorgasmia (-cyproheptadine for) Racer, posted by Questionmark on May 29, 2004, at 20:32:44

> > Periactin worked pretty well to alleviate this particular effect for me. It's a very old antihistimine, and is usually used for off label uses now -- like counteracting side effects from other medications. One of the best things about it is that you take it as needed, and it takes about 20 minutes to kick in.
> >
> > The potential downside, of course, is that it's an anti-histimine. Afterwards, you just roll over and go to sleep. (Sometimes this is a good thing, of course...)
> >
> > I can't say that it was perfect, but it really helped increase my ability to experience pleasure.
> >
> > Hope that helps.
> Racer, thanks for your reply.
> i have a prescription for Periactin (cyproheptadine) that i got a few months ago, but i have only used it a few times, and i don't exactly know how it affects me yet. From my few experiences with it, however, i thINk that the antihistamine effects are too much to benefit from it enough-- i just get too tired and blahhed out (i think). And the one time i took it i felt like crap for most of the next day (i.e., i had that antihistamine hangover that i always get w/ H1 blocking drugs, but i felt even more depressed than i usually do, too)-- which surprised me since i read that cyproheptadine only has a half-life of 4 hours. And because of how crappy i felt, i'm also wondering if the 5-HT2 antagonistic effects have a negative effect on me overall (besides the possible relief of anorgasmia). Oh and i didn't really get much relief from my anorgasmia with it at the doses i used.
> i really need to experiment with it some more. Thank you for the post though. It gives me hope that it might actually work better than i realize so far, and it gives me more motivation to experiment with it some more again.

Cyproheptadine is a H1, 5-HT1 & 5-HT2A antagonist. 5-HT2A blockade relieves anorgasmia, 5-HT1 blockade temporarily stops the antidepressant effect SRI's & MAOI's give which hopefully will increase libido. If your libido is OK or not really a problem, then I would have a look for a 5-HT2A blocker that isn't a 5-HT1 blocker.





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