Posted by djmmm on May 28, 2004, at 7:46:17
In reply to Tegretol and Nardil- Djmmm or anyone!!!!, posted by ace on May 27, 2004, at 23:08:17
> Am i correct in believing Tegretol with Nardil has the following effects
>
>
> 1. Nardil increases plasma levels of Tegretol
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> 2. Nardil blood levels decrease with Tegretol
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> 3. Zyprexa blood levels decrease with Tegretol
>
> BUT- i will only be on 500-700mg Tegretol- surel this lower dose will not cause too much lowering off Nardil and Zyprexa. And it is quite possible that it Tegretol might not even cause any decrease in Nardil and Zyprexa levels...
>
> am i correct...
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> i know djmmm took tegretol + nardil- i dont think he mentioned noticing any difference...
>
> are you out there djmmm!?
>
>
> BTW, I have now started Tegretol!!!
>
> Ace
> Nardil 105mg
> Zyprexa 2.5mg
> Tegretol 400mg
I don't think that there is a significant metabolic interaction between Nardil and Tegretol... typically, tegretol effects the plasma levels of MOST other drugs it's combined with. Tegretol can even induce its own metabolism. I think the two meds are contraindicated because both drugs increase serotonin.Keep in mind that since Nardil is an irreversible MAOI, as soon as adequate MAO is inhibited the drug is designed to be lowered and decreased to a maintenance dose. With this being said, a lowering of serum levels is not as significant a problem as it is with most other drugs...again, I don't think that there is much of an interaction anyway.
Tegretol DOES induce the metabolism of Zyprexa (lowering serum levels of zyprexa)
Free and glucuronidated olanzapine serum concentrations in psychiatric patients: influence of carbamazepine comedication.
Ther Drug Monit. 2002 Aug;24(4):512-7.Olanzapine serum concentrations lowered by concomitant treatment with carbamazepine.
J Clin Psychopharmacol. 2000 Feb;20(1):110-2.Addition of monoamine oxidase inhibitors to carbamazepine: preliminary evidence of safety and antidepressant efficacy in treatment-resistant depression.
J Clin Psychiatry. 1995 Oct;56(10):471-5.
poster:djmmm
thread:351318
URL: http://www.dr-bob.org/babble/20040527/msgs/351415.html