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Re: Terrified....Transitioning to MAOI, going off meds » Sad Panda

Posted by chemist on May 22, 2004, at 1:54:30

In reply to Re: Terrified....Transitioning to MAOI, going off meds » chemist, posted by Sad Panda on May 22, 2004, at 1:32:08

> > >
> > > > hello there, phoenixgirl, from chemist...i had a wonderful run with parnate, literally kicked in the day after i started taking it. i empathize with your concerns about being off all meds for 2 weeks or so, but it sounds as if you have braved the course over the last 12 years or so, and in my opinion, you will come through just fine. you will find on this board many, many posts concerning parnate and nardil, the latter seeming to come off as superior to parnate, from what i have read. in that my experience with parnate was very positive - and that most posts concerning nardil appear to be supportive - it is worth the wait, in my opinion. be strong, and do keep us posted...all the best, chemist
> > > >
> > >
> > >
> > > hey chemist!
> > >
> > > It's great to hear Parnate had such a great effect for you....I have a feeling that Reboxetine would be good for you too.
> > >
> > > However, Parnate induced a terrible depression in me...I believe it is more noradrenergic and dopaminergic than Nardil, and has no effect on GABA....could u confirm this??
> > >
> > > Thanks mate,
> > > Ace
> >
> > hey ace, my recollection is that you are spot-on, i recall epinephrine, NE, and dopamine degradation being inhibited....don't recall if serotonin was/is involved, but given the danger signs for MAOI + SSRI, i should think so...as for GABA, it is a monoamine (primary), and i would expect that parnate blocks (to an extent) deamination of GABA...but i cannot find any literature supporting the GABA business. i spent quite a while combing the literature about 3 years ago looking for positives of metabolites in the phenethylamine class (amphetamine, to be precise, if you can cleave the 3-membered ring) but came up empty. it was quite stimulating for me, but to my detriment, as it pushed me into hypomanic/manic behaviour. let me know if this is in concert with what you have found, or if i'm off......thanks much, and all the best, chemist
> >
> >
> >
>
> If they both affect MAO-A & MAO-B rather than the amines themselves, would that not mean that both would be pretty similiar in their effects 5-HT, NE & DA?
>
> My rough understanding of them is that Nardil itself & metabolites directly affect GABA, while Paranate & it's metabolites are very similiar to amphetamines.
>
> Cheers,
> Panda.
>
>
>
hi panda, right you are...the lit. confirms your assertion in re: GABAnergic activity with phenelzine (and active metabolites)...the forum remains open as to whether tranylcypromine is metabolized to amphetamine, in which case we would be looking at dopamine, NE, and not GABA...thanks for the info, and i stand corrected...all the best, and thanks much! chemist


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