Posted by chemist on April 27, 2004, at 14:25:05
In reply to Re: klonopinchemist » chemist, posted by Kon on April 27, 2004, at 3:16:17
> Thanks chemist. I was specifically referring to tolerance to anti-anxiety effects. I use clonazepam for anxiety and when I researched the drug, all the studies I came across suggested no tolerance wrt anti-anxiety effects. My pdoc also mentioned this (although he used the phrase "very unlikely to develop tolerance"). There is an Ashton article suggesting that tolerance to anti-anxiety effects is inevitable over the long-term but her piece relied on tertiary sources and to the best of my knowledge these views were not based on primary sources. If you are aware of any primary sources suggesting tolerance, I’m very interested in looking at them...
>
> Wrt the Worthington (1998) values, I got them from the "results" section. The decrease was not significant, but I just wanted to point out that there was an insignificant decrease in dose from 6 months to 12 months. Moreover, there was no significant change in dose up to 2 years (again suggesting no tolerance). Similar data (some of which you’ve mentioned in your post) also suggest no tolerance to anti-axiety effects (Davidson, etc.). I would appreciate if you have come across any primary sources that suggest otherwise.
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kon, thank you for the info: let me dig through my resources in re: tolerance for anxiety. given the rather thorough nature of your posts, i get the feeling that my efforts to find primary sources in the public domain will be as fruitful as yours....and turn up the same results....give me some time to do some digging, and thanks again for your info: i am better educated on this matter thanks to you. all the best, chemist
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