Posted by King Vultan on April 26, 2004, at 12:46:02
In reply to Re: MAOI causes hypotension - What's the mechanism? » King Vultan, posted by SLS on April 25, 2004, at 11:16:28
> Todd, can you do me a favor and use your book to retrieve the Ki values at the NE alpha-1 receptor for a few drugs if it is not too much trouble. Hopefully, they will be listed as nanomoles, but if not, I guess I can convert them. I'd like to use them to update my chart.
>
> imipramine
> desipramine
> amitriptyline
> nortriptyline
> phenelzine
> tranylcypromine
> fluoxetine
> sertraline
> paroxetine
> venlafaxine
> bupropion
> mirtazapine
>
>Sorry, I only have half of the ones you listed:
------------------------Ki
---------------------Alpha-1
------------------Human cortex
---------------(cadaver tissue used)amitriptyline..........4.4 +/- 0.2
desipramine............23 +/- 1
paroxetine.............995 +/- 35
sertraline................36 +/- 2
fluoxetine............1353 +/- 17
venlafaxine........39921 +/- 810FWIW, it also lists
nefazodone.............5.5 +/- 0.3
trazodone................12 +/- 0.2As a comparison, phentolamine is listed as 3.4
Todd
poster:King Vultan
thread:339531
URL: http://www.dr-bob.org/babble/20040423/msgs/340207.html