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Re: Please!! Need Advice on Klonopin usage judy1

Posted by chemist on April 18, 2004, at 21:02:50

In reply to Re: Please!! Need Advice on Klonopin usage chemist, posted by judy1 on April 18, 2004, at 19:25:30

> Hi,
> I probably should have been clearer about my dx- BP 1/ panic disorder, so in my case klonopin is used as a secondary MS (hence the fairly high dose) as well as treating panic disorder. I also have taken all the benzos, and still take xanax prn if I'm in the midst of a panic attack. I also found klonopin to be somewhat more depressing than xanax, and if I did not have bipolar disorder I would most likely use xanax also.
> take care, judy

hi judy....klonopin has a half-life ranging from 18-50 hours, and the upper figure is probably more accurate. further, klonopin loses much of its efficacy after about 6-8 months, i.e., you hit the wall in terms of what it can do for you. valium has an even longer half-life - almost 1 week or longer - and i suspect that your lethargy is due to the klonopin buildup (you never have time for it to get out of your system, and you are taking quite a substantial dose). xanax is excellent prn for panic, but have you considered ativan, which does not cross the blood-brain barrier as quickly as valium (on a prn dosing, not chronic, and this is due to the presence of 2 chloro substituents in ativan vs. one in valium, plus there is a hydrophobic methyl group in valium that is not present in ativan, fyi) *but* ativan has a short half-life and a longer reidence time once it does cross the blood-brain barrier (up to about 1 day). you would feel less sluggish, and your system would have time to clear out the ativan so that the effectiveness would remain steady....let me know, and all the best, chemist




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