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Re: Please!! Need Advice on Klonopin usage terrics

Posted by chemist on April 18, 2004, at 16:03:03

In reply to Re: Please!! Need Advice on Klonopin usage chemist, posted by terrics on April 18, 2004, at 9:33:50

> Hi Chemist, Just want to ask you a question about memory loss or more accurately memory slow-down. I saw that you posted klonopin causes memory problems and that is one of my meds. How about these; do they cause any memory complications? effexor xl, lithium xl,wellburin xl, inderal. thank you. terrics

hi terrics....first, you will certainly be getting memory problems from klonopin, as from any benzo: this is a fact of life for these drugs. second, your lithium can cause cognitive impairment, even in the therapeutic dose range. now for effexor and wellbutrin and inderal. the white sheet in my PDR for effexor states that little to no cognitive impairment results from its administration, however, tucked further back in the section on adverse effects during premarketing trials, confusion and thinking abnormal are listed as having occurred as ``frequent,'' i.e., in at least 1 in 100 of the patients (here, 5356) involved in the trials. inderal has been shown to have adverse effects (and i quote) ``short-term memory loss,'' although the good folks at wyeth note that ``Most adverse effects have been mild and transient...'' wellbutrin might be a troublemaker with inderal, in that you might have to back-of the dosage of inderal due to wellbutrin being an inhibitor of the CYP2D6 enzyme that metabolizes inderal. during premarketing studies, memory loss was reported as infrequent (between 1/100 and 1/1000). now, more on lithium: a prety recent review entitled ``the effects of lithium on cognition: an updated review,'' pachet and wisniewski. psychopharmacology (berl.) 170:225-234 (2003) - i just read the abstract - concluded that 5 themes emerged fromtheir study: impairment of tasks of psychomotor speed; impaired functioning in studies involving verbal memory; no impairment of visuo-spatial constructional ability; no negative cumulative effect. this is the tip of the iceberg on lithium: hit pubmed (www.pubmed.org) and use keywords lithium and cognitive and see for yourself.....hope this helps, let me know! all the best, chemist


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