Posted by PsychoSage on April 5, 2004, at 19:17:47
In reply to Re: effexor and ectasy -LINK, posted by scott-d-o on April 5, 2004, at 16:40:59
> > Correct me if I'm wrong, but a reputake inhibitor could potentially increase the toxicity caused by MDMA.
> >
> > MDMA causes serotonin to be released from the terminals, and a reputake inhibitor would stop it from being metabolised. This would equal an increased level at the synapse.
> >
>
> exhaustingly explained in another post in this thread. reuptake transporters don't metabolize serotonin; monoamine oxidase-A (MAO-A) does. for the answer to why ssri's attenuate mdma-induced 5-HT release, see my other post.
>
> > Whats wrong with you anyway? I mean really. All of us here are trying to get better from a mental illness. If you're on an antidepressant that means you were depressed at one point. Just cause you're feeling better doesn't mean its time to go ahead and start abusing your brain. Forget the theory, it's just plain a bad idea.
> >
>
> What's wrong with me? I apologize for trying to clear up all the misinformation being passed around here. I think people would rather hear the real deal instead of a "just say no" response plagued with false information. I'm not advocating mdma's use, I was merely setting the record straight. He's going to do whatever he wants with his brain regardless of your scare tactics and misinformation. I happen to believe human beings are intelligent and capable enough to make these types of decisions regarding their own body.
>
> scottThe real deal is that I suffered from serotonin syndrome/amphetamine poisoning {however you want to look at it} twice in two weeks on different sides of the country with EFFEXOR, and I was on nothing else. Both times were with meth, and they were not from the same source. I was in the hospital both times. Embarrassingly, the second time was at my university's hospital.
I am indifferent as to whether MDMA causes direct or indirect
serotonin release. I watched a friend who was on prozac when she was unable to appreciate any of the pleasureable feelings from her pill, and she was kind of pissed. Then she became incredibly ill with the classic serotonin syndrome symptoms.An SSRI or an SNRI doesn't merely dampen the effects of a pill of E. Whether the pill becomes useless for recreational purposes and if the pill and the medication actually cause illness could be two situations along the same continuum which ultimately ends at fatal serotonin poisoning as far as I am concerned.
Anyways, if you choose to be risky, stop your meds for 1-2 weeks period.
Personally, I feel the bad information out there about ecstacy can be pretty well isolated.
http://www.maps.org/forum/2003/msg00573.html in this link is a full copy of the nytimes.com article and another link to the original article in the nytimes.com but sometimes an article may be archived and will require a fee to access it.
poster:PsychoSage
thread:332813
URL: http://www.dr-bob.org/babble/20040402/msgs/333052.html