Posted by rod on April 5, 2004, at 16:17:14
In reply to Re: effexor and ectasy -LINK » scott-d-o, posted by PsychoSage on April 5, 2004, at 13:04:30
> > > thanks loads for all the replys. some of you seem very informed. it seems the ectasy and effexor won't mix.just out of intrest what does seratonin poisening do? is it fatal?
> >
> > no need to worry about serotonin syndrome from this combination. ecstasy (3,4-methylenedioxyamphetamine) releases serotonin via reversing the action of the serotonin transporter (SERT), causing it to release serotonin into the synapse instead of taking it up into the cell like it normally does. effexor would almost entirely block any serotonin release induced by mdma, via it's occupation of the SERT. however, the supposed neurotoxicity of mdma is believed to be caused by excess dopamine at serotonin terminals. this seems to be a bunch of b/s thou and doesn't occur when the compound is used at common "recreational" doses.
>
> Wait a second. Is this hypothetical or official information from NIDA?
>
> It doesn't make sense whatsoever. We often through around our imperfect interpretations of studies and medical information, but I think when it comes to this particular issue where no doctor is accountable then we have to raise the bar here and not confuse neurotoxic rhetoric from the government with serotonin syndrome which is not a principal argument from anyone who wants to scare American youth away from ecstacy.
>
> If you think the warnings about serotonin syndrome here are influenced by flawed neurotoxicity research then you are entirely wrong.
>
> I am not keen on neuroscience specifics, but an agonist and a reuptake inhibitor do not cancel each other out.
>
> Specific Drug interactions and Serontonin syndrome:
> http://www.currentpsychiatry.com/2003_05/0503_serotonin.asp<nerd mode turned on>
Scott-d-o is perfectly right. Thats what current science knows about this. I have a good paper, but ist a pdf and i dont have a link and the copy and paste function does not work whyever. But here is something similar good:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12404538
"..Citalopram markedly reduced most of the subjective effects of MDMA, including positive mood, increased extraversion and self-confidence. Cardiovascular and adverse effects of MDMA were also attenuated by citalopram.."And about your link. this person was taking Lithium plus Phenelzine (Nardil MAOI). Thats a really bad idea
And MDMA is not a direct serotonin agonist. It does not dock and tickle the receptor directly. Like Scott-d-o said, it causes the release, which gets blocked by an SSRI.
<nerd mode turned off>
Dont waste your money. It wont work. And dont risk anything, cause you never really know what you actually get... It just doesnt make sense to take a drug which is known to cause or worsens various mental disorders, if one already has problems and takes a medication to treat this.
Roland
poster:rod
thread:332813
URL: http://www.dr-bob.org/babble/20040402/msgs/332974.html