Posted by King Vultan on March 14, 2004, at 11:04:45
In reply to Re: Mirapex for SSRI SD » dondon, posted by Questionmark on March 14, 2004, at 2:57:08
> > Will this work to reverse the sexual side effects? Or do ssri's have a dopamine antagonist effect that make it not work?
>
> It is supposedly able to help a good deal. And no, SSRIs do not have a direct DA antagonist effect.
>
>If you look at sexual function as being divided into three phases, desire, arousal, and orgasm, SSRIs can have direct negative effects in both the desire and orgasm phases. The mechanism is slightly different in each case, however. The problems in the desire phase are thought to be caused by stimulation of serotonin 2A receptors in the brain, with reduction of dopamine in the brain's pleasure centers. The orgasm problems are thought to be due to stimulation of serotonin 2A receptors in the spinal cord, with inhibitory effects on the reflexes involved in orgasm. In either case, a drug that blockades serotonin 2A receptors such as trazodone or Remeron should theoretically correct the problem, but a pro-dopaminergic agent such as Wellbutrin or Mirapex would appear to mainly be useful only for those problems that are primarily libido related.
poster:King Vultan
thread:323962
URL: http://www.dr-bob.org/babble/20040313/msgs/324241.html