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Re: Lexapro vs. Zoloft (sexual side effects) » SPhobia

Posted by scott-d-o on March 4, 2004, at 10:24:12

In reply to Re: Lexapro vs. Zoloft (sexual side effects), posted by SPhobia on March 3, 2004, at 19:31:28


> Zoloft: I'm up to 100mgs/day at this poing and have been titrating up on it for about 3 weeks. I may have a "slight" decrease in libido, but its so slight I am beginning to think it's my imagination (or due to increased stress in my work life). I am having NO PROBLEMS WITH ORGASMING!! This is the big one for me...I can't understand why Z has been SO different in this area for me than Paxil and Lexapro were. But who cares, I couldn't be happier about it. Also, I do NOT seem to be having the concentration problem I had on paxil.
>

this is not suprising, since zoloft has a higher selectivity ratio for the da transporter vs. 5-ht transporter (ic50[5-ht] / ic50[da]) than any of the other ssri meds. generally, more da = less sexual se's, same goes for attention problems.

scott


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