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Effexor bears little structural similarity to PCP

Posted by Jaynee on January 20, 2004, at 21:26:39

In reply to effexor can cause a false/positive pcp result, posted by Jaynee on January 20, 2004, at 21:13:47

Venlafaxine, designated (R/S)-1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl] cyclohexanol, is a phenethylamine derivative that is chemically unrelated to tricyclic, tetracyclic, and other antidepressants. It is the first antidepressant in a new drug class referred to as the serotonin noradrenergic reuptake inhibitors (SNaRIs) (4). Aside from possessing phenyl and cyclohexyl groups, venlafaxine bears little structural similarity to phencyclidine [1-(1-phenylcyclohexyl)piperidine; see Fig. 1 ]. Given this structural dissimilarity, it is somewhat surprising that venlafaxine or any of its desmethyl metabolites would cross-react with the anti-PCP antibody used in the RapidTest device. However, other examples of unexpected interferences with immunoassays for drugs of abuse have been well documented in the literature, e.g., oxaprozin with the Emit assay for benzodiazepines (5) and efavirenz with the CEDIA test for cannabinoids (6)(7).




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