Posted by Ilene on November 15, 2003, at 11:59:57
In reply to Catecholamine Response to Exercise, posted by Kacy on November 14, 2003, at 19:20:52
> Below is another piece that I saw recently. It's a study on kids. It says that they didn't get a dopamine increase after exercise like the controls, and that they only got one-third the norepinephrine increase the controls got.
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> Reading this study made me sad. I don't like to think about it, even though I've always known. I'd like to call up an old therapist and tell her not to tell everyone they'll feel better if they exercise. She kept saying that. Never worked for me. Think twice before you tell people what exercise will do for them.
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> Catecholamine Response to Exercise in Children with Attention Deficit Hyperactivity Disorder.
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> Pediatr Res 2003 Mar 5; [epub ahead of print]
> "The objective of this study was to examine differences in catecholamine (CA) response to exercise between children who had received a diagnosis of attention-deficit/hyperactivity disorder (ADHD) and age- and sex-matched controls. On the basis of the notion of a CA dysfunction in ADHD, we reasoned that the normal robust increase in circulating CA seen in response to exercise would be blunted in children with ADHD. To test this, we recruited 10 treatment-naive children with newly diagnosed ADHD and 8 age-matched controls (all male) and measured CA response to an exercise test in which the work was scaled to each subject's physical capability. After exercise, epinephrine and norepinephrine increased in both control and ADHD subjects (p = 0.006 and p = 0.002, respectively), but the responses were substantially blunted in the ADHD group (p = 0.018) even though the work performed did not differ from controls. Circulating dopamine increased significantly in the control subjects (p < 0.016), but no increase was noted in the subjects with ADHD. Finally, a significant attenuation in the lactate response to exercise was found in ADHD (between groups, p < 0.005). Our data suggest that CA excretion after exercise challenges in children with ADHD is deficient. This deficiency can be detected using a minimally invasive, nonpharmacologic challenge." [Abstract]
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> Can anyone tell me what this means? …"a significant attenuation in the lactate response to exercise was found in ADHD."
>I know lactic acid builds up in muscles during exercise--I think it's the end product of one of the energy-producing metabolic cycles--but I'm sure Larry Hoover or someone else who actually remembers their biochem can tell us for sure. Must be related to "lactate response". Now you've got me curious and I will have to do a web search.
Exercise never did anything for me and I never built much muscle. I think I'm just physiologically abnormal because my blood pressure drops and I probably can't get enought oxygen to my muscles when exercise. I also resent all the advice I got or read about, because I can't do any of it without becoming more impaired.
About this study: my guess is they took blood samples and looked at CAs circulating through the *body*. Aren't the CAs in the brain the ones of interest? Is there a correlation? I thought that was one of the problems with diagnosing and treating depression--you couldn't do a simple blood test and determine that a person had low levels of norepinephrine or whatever.
Ilene
poster:Ilene
thread:278752
URL: http://www.dr-bob.org/babble/20031111/msgs/280001.html