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Catecholamine Response to Exercise

Posted by Kacy on November 14, 2003, at 19:20:52

In reply to Re: Exercise Boosts Drug Treatment for Depression, posted by SLS on November 14, 2003, at 8:29:05

Exercise never makes me feel better. I feel better about myself if I am in shape, but the exercise itself doesn't do anything positive for me in terms of making me feel better. I've done plenty of it to know, including a full-hour of Super Advanced Aerobics. (No short, 50-minute hour for us, and we got our stretching done before class.) Those 3 x a week classes were only half my exercise schedule.

I read an explanation for that in a profile for inattentive Add. The exercise high is from dopamine and, of course, Adders are short on the ability to make dopamine–even from exercise. Another point made was that we made muscles easily. Reading that gave me one of those "Oh, my God" moments. I had always said that I make muscles like a man. I try not to give other women exercise advice because of that. I realized a long time ago that they couldn't develop muscle anywhere near as quickly as me.

Below is another piece that I saw recently. It's a study on kids. It says that they didn't get a dopamine increase after exercise like the controls, and that they only got one-third the norepinephrine increase the controls got.

Reading this study made me sad. I don't like to think about it, even though I've always known. I'd like to call up an old therapist and tell her not to tell everyone they'll feel better if they exercise. She kept saying that. Never worked for me. Think twice before you tell people what exercise will do for them.


Catecholamine Response to Exercise in Children with Attention Deficit Hyperactivity Disorder.

Pediatr Res 2003 Mar 5; [epub ahead of print]
"The objective of this study was to examine differences in catecholamine (CA) response to exercise between children who had received a diagnosis of attention-deficit/hyperactivity disorder (ADHD) and age- and sex-matched controls. On the basis of the notion of a CA dysfunction in ADHD, we reasoned that the normal robust increase in circulating CA seen in response to exercise would be blunted in children with ADHD. To test this, we recruited 10 treatment-naive children with newly diagnosed ADHD and 8 age-matched controls (all male) and measured CA response to an exercise test in which the work was scaled to each subject's physical capability. After exercise, epinephrine and norepinephrine increased in both control and ADHD subjects (p = 0.006 and p = 0.002, respectively), but the responses were substantially blunted in the ADHD group (p = 0.018) even though the work performed did not differ from controls. Circulating dopamine increased significantly in the control subjects (p < 0.016), but no increase was noted in the subjects with ADHD. Finally, a significant attenuation in the lactate response to exercise was found in ADHD (between groups, p < 0.005). Our data suggest that CA excretion after exercise challenges in children with ADHD is deficient. This deficiency can be detected using a minimally invasive, nonpharmacologic challenge." [Abstract]


Can anyone tell me what this means? …"a significant attenuation in the lactate response to exercise was found in ADHD."


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poster:Kacy thread:278752
URL: http://www.dr-bob.org/babble/20031111/msgs/279858.html