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Re: Without doubt: CLORGYLINE Jack Smith

Posted by SLS on October 18, 2003, at 18:02:02

In reply to Re: Without doubt: CLORGYLINE SLS, posted by Jack Smith on October 18, 2003, at 17:28:20

Hi Jack.

Thanks for your supportive sentiments.

I'm glad to know that your holiday from Psycho-Babble has been a positive one. I hate to disappoint you (and me), but I am not doing so well currently. My "loud" reference to clorgyline was meant to be a general statement. It is probably the single most efficacious antidepressant out there. For the time that I was on it, it was the only thing that was able to break through the wall and leave me slightly more responsive to other medications. No other single drug used monotherapeutically has been as helpful to me. In the past, the NIMH (National Institute of Mental Health) used clorgyline as its "ace-in-the-hole" when all else failed. Unfortunately, it is no longer manufactured for human consumption, although it is available as a biological probe in animal studies.

Clorgyline is an irreversible, selective MAO-A inhibitor. For quite a while, it was thought that it was the inhibition of the MAO-A enzyme that was most responsible for the therapeutic properties of MAOIs. That selegiline (L-deprenyl) is inferior to Nardil and Parnate in the treatment of depression would support this idea. Three drugs that I would love to see made available are clorgyline, amineptine, and nomifensine. Sometimes, I wish I were a rat.


- Scott

 

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