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Re: Without doubt: CLORGYLINE SLS

Posted by zeugma on October 19, 2003, at 11:47:54

In reply to Re: Without doubt: CLORGYLINE zeugma, posted by SLS on October 18, 2003, at 22:13:35

> > Scott,
> >
> > I am sorry to hear you are not doing well.
>
> Thanks. Better days are coming.
>
> > I know why amineptine and nomifensine were withdrawn, but what happened with clorgyline? Was there some kind of toxicity associated with it?
>
> Clorgyline has been around since the 1960's. For some reason, it was never actively pursued as a marketable antidepressant, although it has seen some use in clinical investigations. It was even looked at for use in ADD / ADHD. In speaking with a doctor at the NIMH, I discovered that a few people taking clorgyline died of cardiac arrest. However, this might have been nothing more than bad luck, as the number of probands was so small. Also, the dosages used in early investigations were two high. 15mg is about as high as one would need to go, and they were using 30mg on children. The patent on clorgyline must surely have expired by now, and there is too little demand for MAO inhibitors to encourage a drug company to bring it to market. If it were out there, I would be taking it right now and combining it with a tricyclic.

I've seen clorgyline mentioned in some of the literature on ADD. I think pargyline was also used- that's a MAO-B inhibitor right? The names are similar, I might be confusing them. I suspected that it was at least in part the MAOI stigma that led to its withdrawal, similar to what happened to Marplan. Sometimes I think the treatment of depression has actually regressed over the last 30 years.
>
> For now, I have my fingers crossed that my recent addition of Remeron to a combination including imipramine and Effexor will bear fruit.
>
> I hope the 'California rocket fuel' lives up to its name and blasts you into a stable orbit, emotionally speaking!


> - Scott

z


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