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Re: why klonopin ? » Francesco

Posted by pseudonym on August 30, 2003, at 11:06:52

In reply to why klonopin ? » pseudonym, posted by Francesco on August 30, 2003, at 7:57:11

The reason for choosing Klonopin is that this molecule in studies its been shown to work efffectively for social anxiety without sexual side effects.

All benzos do not work with same.
Klonopin binds at the GABA receptors and "enhance" GABA, an inhibitory neurotransmitter, at the binding site. So do other benzos, you're correct in that.

However, there are multiple kinds of GABA receptors, only one subtype of which, when bound, reduces anxiety. Others sedate you. The various benzos have diffential affinity for these different gaba receptors, and correspondingly produce different effects.

I'm speculating here, but it may well be that Klonopin has a higher anxiolytic receptor subtype binding relative to its peers, or failing that, doesn't bind as well to the non-anxiolytic GABA subtypes.

But like you, I need to still handle the anhedonia porition of social anxiety, hence the dopaminergic quest I am on.


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