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Re: Effexor metabolite in Phase III testing

Posted by SLS on July 10, 2003, at 16:16:16

In reply to Re: Effexor metabolite in Phase III testing, posted by djmmm on July 10, 2003, at 15:23:28

> I think they singled out the O-desmethylvenlafaxine metabolite because the N-desmethyl and N,O,-didesmethyl metabolites are less active (not as potent) as the parent drug

Do you know if the ratio of potency for 5-HT versus NE reuptake inhibition is closer to 1:1?

- Scott




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