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Re: Effexor metabolite in Phase III testing

Posted by stjames on July 10, 2003, at 14:45:28

In reply to Re: Effexor metabolite in Phase III testing, posted by djmmm on July 10, 2003, at 14:06:00

> I heard about this, it's desvenlafaxine (O-desmethylvenlafaxine) it is slightly more potent than the parent drug, and it's half life is about 10 hours compared to venlafaxine's 4 hour half-life.

This would be a very useful "least patentable difference". I wonder the effect of taking just one active vs many actives (from the parent) &
if there is any synergy between the actives




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