Posted by sciutti on July 6, 2003, at 19:51:59
In reply to Re: Serotonin, etc in Depression--your rebuttal » Caleb462, posted by Caleb462 on July 3, 2003, at 2:25:17
> > >> It has NOT been well established that depression stems from problems with serotonin/NE/dopamine balance/depletion.
> >
> > Well, maybe not WELL established, but so far, from all I've read, these chemicals definitely play a part. I would appreciate your citing an article or two that refutes the current hypothesis.
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> >
> >
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> I've no doubt they play a part in psychiatric disorders, but how, why, and to what extent... who knows?
>
> My personal belief is that the large majority of major depressive episodes stem from chronic, recurrent stress... which throws the system out of whack in some way... in what way, no one exactly knows. Excess cortisol release could certainly be one thing...
>
> I've run across several articles refuting the "monoanime hypothesis" of depression, though I don't have them archived, unfortunately. I will find them again, and post thim when I do.
I still don't know how to use message boards. So I'll try this....I sent Dr. Bob a question. Is that "proper" cuz I haven't gotten any replies, but I understand that. Have been reading posts on causes, drugs, etc. and I have done a lot of research. The web site for the monamine hypothesis I think is - http://www.biopsychiatry.com/mechnov.htm. and very informative.
With long term use of AD there have been found to be increases in both serotonergic and dopaminergic function ie long term use induces adaptive changes in pts. system. To me, that sounds plausible and may explain why they work.
Sorry if I offended anyone in subject content, but it just popped into my head cuz does it really matter WHY they work or just that meds do work? I am so guilty of researching and wanting to know the why and this sounds so hypocritcal, so sorry. Joanne
poster:sciutti
thread:238497
URL: http://www.dr-bob.org/babble/20030701/msgs/239727.html