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Re: maoi plus wellbutrin

Posted by shrimp on June 18, 2003, at 17:33:49

In reply to Re: maoi plus wellbutrin » shrimp, posted by jemma on June 18, 2003, at 10:33:54

Hi Jenna,

Yes, I am one of those annoying patients who calls my doctor every other day on a side effect. I guess the blurred vision goes along with the hypotension. The twitches have gotten better since i reduced the Wellbutrin, but they are definitely still there, when i have an exciting or happy thought i twitch!! I've learned to laugh at it, but it is bizarre. My pdoc seems to think these side effects are no big deal compared with how depressed i was (suicidal), and i guess he is right, but the depression is not gone yet, it is just a little better. Oh, and i'm also constantly constipated!! I have to take this medicine called colase every single day for that. I feel like a 90 yr. old with all these side effects.


> Have you told your pdoc about the twitches, the blurred vision, and the orthostatic hypotension? The combined action of monoamine oxidase inhibition - which raises levels of dopamine, norepinephrine, and serotonin - and wellbutrin - which inhibits reuptake of dopamine, norepinephrine, and serotonin - does seem to risk potentially dangerous levels of all three, especially serotonin. I think it would be wise to let him know you're having trouble.
>
> - Jemma
>
>
>
>
>
> > Jenna,
> > I didn't know you could combine the two either, but i trust my p-doc, he's good. I think it is a novel combination though, and he had some reservations, because i increased the nardil very, very slowly. I was on 45mg been on 60 mg. for about 2 weeks, still waiting for it to kick in. Actually, i do feel better, but i still have lethargy, lack of motivation, and anhedonia.
> > Hope that helps.
> > Shrimp
>
>


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