Posted by Ritch on June 7, 2003, at 11:00:46
In reply to Re: The lore of talked-off legs----- » Ritch, posted by Squiggles on June 7, 2003, at 7:05:45
> Are you sure lithium lowers the seizure
> threshold -- does it mean that lithium
> over the "therapeutic index" is likely
> to induce seizures?
>
> Thanks
>
> SquigglesHi, yes it lowers the seizure threshold. It doesn't do it like a lot of antidepressants can do however, from what I understand. Oh, just because your "seizure threshold" has been lowered a little isn't anything horrible really-a lot of meds can do that. I'm not absolutely sure, but it seems likely that as the serum lithium level rises the seizure threshold falls accordingly. Don't know how "linear" that relationship is, though. High serum levels are likely to make you feel crummy and give you diarrhea or something rather than cause a seizure. But the risk is there.
poster:Ritch
thread:231713
URL: http://www.dr-bob.org/babble/20030604/msgs/232144.html