Posted by Caleb462 on May 28, 2003, at 22:22:16
In reply to Re: DOES anyone know the mechanism behind this?, posted by jemma on May 28, 2003, at 10:12:58
> I wonder if part of the answer isn't very simple. Seratonin is a vasoconstrictor, and inhibits the vasodilation needed for optimal sexual performance. Antihistamines are vasodilators. Just a thought.
>
> - JemmaHmm... well, I believe most of the sexual problems from SSRIs arise from overactivity at 5-HT2c receptors, which inhibits dopamine release and thus blunts the sexual response. Not that vasoconstriction doesn't play a part, I just can't say... as I'm not very knowledgeable on the subject. Also... the only anti-histamine I've read about being able to revere SSRI sexual dysfunction is Claritin. Diphenhydramine, promethazine, hydroxyzine... there are no reports of these having a pro-sexual effect, and in my experience, none of them have helped. I haven't tried Claritin yet either.
poster:Caleb462
thread:229226
URL: http://www.dr-bob.org/babble/20030525/msgs/229852.html