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Re: DOES anyone know the mechanism behind this?

Posted by Caleb462 on May 28, 2003, at 22:22:16

In reply to Re: DOES anyone know the mechanism behind this?, posted by jemma on May 28, 2003, at 10:12:58

> I wonder if part of the answer isn't very simple. Seratonin is a vasoconstrictor, and inhibits the vasodilation needed for optimal sexual performance. Antihistamines are vasodilators. Just a thought.
> - Jemma

Hmm... well, I believe most of the sexual problems from SSRIs arise from overactivity at 5-HT2c receptors, which inhibits dopamine release and thus blunts the sexual response. Not that vasoconstriction doesn't play a part, I just can't say... as I'm not very knowledgeable on the subject. Also... the only anti-histamine I've read about being able to revere SSRI sexual dysfunction is Claritin. Diphenhydramine, promethazine, hydroxyzine... there are no reports of these having a pro-sexual effect, and in my experience, none of them have helped. I haven't tried Claritin yet either.




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