Posted by djmmm on May 27, 2003, at 15:41:35
In reply to Re: DOES anyone know the mechanism behind this?, posted by Jaynee on May 27, 2003, at 14:41:34
> It's not Claritin-D. My doc told me that Claritin does cross the brain barrier.
I'm not a Dr. but I think your Dr. may have mispoken. The reason why the second generation antihistamines are non-sedating, is because they act on peripheral H1 rather than central H1 receptors.
From what I understand (I may be wrong) the positive anti-allergy effects from Claritin (loratadine) may actually be from its metabolites, primarily desloratadine, which also does not cross the BBB, thus the lack of sedation, etc.
Desloratadine may be what is contributing the positive response you are experiencing, since desloratadine has a myriad of effects (anti-inflammatory , and inhibition of superoxide--often associated with male sexual dysfunction).
poster:djmmm
thread:229226
URL: http://www.dr-bob.org/babble/20030525/msgs/229485.html