Posted by Larry Hoover on May 21, 2003, at 13:55:31
In reply to Re: Mitral Valve Prolapse and ADs » Larry Hoover, posted by mattdds on May 17, 2003, at 14:38:50
> Larry,
>
> This research is really interesting. Have you gotten any obvious effects from magnesium?Well, I kind of wish I could go in for another echocardiogram, as I was diagnosed with MVP about a decade ago, before I got into supplements. I'd really like to know if I still have the same degree of regurgitation.
I've found recently that magnesium makes me dopey and subdued. That was not previously the case, so maybe I've "fixed" that part of my biochemical soup already.
>I found it interesting that it attenuated catecholamine release, which it (subjectively) feels like is my problem. It feels like I have a hair-trigger catecholamine release, or something. Sounds like Mg works something like benzos, in the sense that they prevent spikes of catecholamines. Does the magnesium attenuate catecholamine release centrally as well? Or just peripherally?
Hypersensitivity to stimuli is indeed associated with magnesium deficiency. The threshold for what is seen as novel (or surprising, if you will) is diminished in hypomagnesia.
If I recall correctly, magnesium attenuates glutamate (excitatory) receptor sensitivity, and thereby directly inhibits release of norepinephrine and epinephrine.
With respect to catecholamines, I'd surmise that central and peripheral effects would be similar.
> What is the best type of magnesium supplement? I remember reading somewhere that the oxides of Mg are essentially worthless as supplements, as they are not absorbed well. Or are they all the same?
MgO is not worthless, it's just worth less. MgO is not very soluble, even in acid, so that's the key consideration. Fully soluble magnesium salts like magnesium citrate, or mag sulphate (epsom salts) or chelates like the glycinate, are almost totally bioavailable. Start off with low doses initially, as a primary magnesium deficiency takes time to overcome. As your body adjusts to the enhanced availabilty of magnesium, it will ramp up the uptake mechanisms. Too much of any magnesium salt will induce diarrhea, which actually pulls magnesium out of the body.
> Thanks,
>
> MattWelcome.
Lar
poster:Larry Hoover
thread:227225
URL: http://www.dr-bob.org/babble/20030520/msgs/228098.html