Posted by Donna Louise on May 18, 2003, at 15:44:18
In reply to SSRI (Paxil) + Mirapex?, posted by JohnB55 on May 15, 2003, at 12:21:00
> Ame Sans Vie,
>
> You recently wrote here:
>
> "I've read dozens of clinical studies that evaluate the drug Mirapex (pramipexole- and anti-parkinson drug) as being a terrific antidepressant, as well as working beautifully for anhedonia, lack of motivation, dysthymia, reward, and even SSRI-induced apathy"
>
> I am looking for a med that will alleviate the SSRI-induced apathy that I experience due to excessive SSRI-induced daytime sedation. I am currently taking Paxil at much-lower-than-normal doses (less than 5mg per night) which works ok somewhat for my depression, but I really need to take the Paxil at normal doses (such as 20mg per night or higher) in order for the Paxil to effectively deal with my anxiety/OCD.
>
> My problem is that the Paxil is too sedating for me at the normal adult dosing level, and thus I am looking for something to alleviate Paxil's daytime sedative effect upon me so I can take the Paxil at normal adult dosing levels such as 20mg per night or higher.
>
> I have already tried Wellbutrin, but it didn't seem to help, that is why I am interested in what you wrote about Mirapex helping SSRI-induced apathy.
>
> Do you think that Mirapex might help alleviate the apathy that I experience due to Paxil's sedative effect upon me?
>
> Also, where can I obtain some clinical studies on the web that would explain Mirapex's benefits for SSRI-induced apathy, just in case I need to make the case to my pdoc.
>
> As I understand from what I have read here, I would still need some kind of SSRI AD med for my anxiety/OCD, since Mirapex itself is not an effective treatment for anxiety/OCD, correct?
>
> Thanks,
>
> JohnB
>Dear John,
I know exactly how you are feeling. I too apparantly need the SSRI for the type of depression and anxiety I have yet it seems to create a new kind of depression of its own. I have been taking 400mg of Provigil and I feel like I have my life back. It seems to be reversing the effects of the SSRI like apathy and sleepiness. I love this drug, no side effects, may even be improving the sexual side effects some too. I had to start with 50 mg but was able to move up pretty quickly. 200mg was not enough for me to achieve all these great benefits and now that it has been almost 6 weeks and I keep feeling better, I am starting to relax and believe this is real!
Hope this helps,
Donna
poster:Donna Louise
thread:221744
URL: http://www.dr-bob.org/babble/20030514/msgs/227440.html