Posted by SLS on March 17, 2003, at 8:39:04
In reply to Abilify not inducing seizures, posted by canwetalk on March 17, 2003, at 8:12:06
> Someone had suggest I direct this message to SLS hopefully SLS can help me. Just wondering what is it in the med Abilify that does not induce seizures. My daughter has been on other anti-psychotic meds and it has induced seizures.
Hi.I am sorry to disappoint you, but I don't know the answer to your question. I don't know what it is about neuroleptic antipsychotics that lowers the seizure threshold in the first place. In fact, there is still some debate as to whether they really do or not. However, clozapine is one neuroleptic that does demonstrate an increased risk of seizure in a dose-dependent fashion. Again, I do not know through what mechanisms this occurs.
Abilify differs from the other antipsychotics in that, according to a few studies, it does not act to block D2 receptors in an area of the brain called the striatum. All the others do. This area is involved in body movement. Scientists look to this as the reason why Abilify does not cause EPS movement abnormalities as often as other neuroleptics. However, it seems that Abilify does cause akathisia, a side-effect producing a sense of inner restlessness and agitation, at rates substantially higher than the other atypical antipsychotics, including Geodon.
- Scott
poster:SLS
thread:208723
URL: http://www.dr-bob.org/babble/20030314/msgs/209941.html