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Re: buspirone and ssri's-not for everyone! » zeugma

Posted by hildi on February 8, 2003, at 20:25:27

In reply to Re: buspirone and ssri's-not for everyone! » hildi, posted by zeugma on February 7, 2003, at 12:33:05

> > This is interesting. So some of you are having positive results from the combo of buspar and SSRI's I was on buspar many years ago, and although it did help a bit, it didn't really take care of the anxiety I have, nor did it touch the depression.
> > Dr. insisted I go on prozac and finally I did, and I took the buspar/prozac combo for quite a while. After a while I got hypomanic and extremely sad. My sadness became constant and so did mania. Finally it turned into worse depression. I read many 'brain books' and med books, and came across information that said you shouldn't ever combine the two: prozac and Buspar. Well, by the time I came across this article I had been so depressed I was crying all the time and sexually obsessed- (not a good thing when it is an obsession) and I had already quite the buspar and was only taking prozac. After a while I felt good again.
> > I never did make a copy of that article I read, but I do have another source of information from another book on meds that also states this: the combination of SSRI's and buspar can produce negative effects.
> > This is definately what happened to me.
> > The negative effects far outwieghed the positive.
> > Hildi
>
>
> The info I've come across states that Buspar and Prozac diminish each other's effects. Maybe that's why many find Buspar a paltry med? It also lowers serotonin levels, so that might explain your sadness (actually that is the diminishment effect). But it might interact more favorably with a more noradrenergic med (like the TCA I'm on).Strange as it it sounds, my depression doesn't take the form of excessive sadness- more of an 'out-of-it,' disjointed feeling (something like mild dissociation, which was extreme during adolescence) and the Buspar seems to partially counter that. My therapist thinks maybe I should go on a stimulant sometime- Provigil maybe? or if I can gain enough weight on my current meds, I might consider trying Ritalin again. Until then, I am dependent on caffeine for the alertness factor- my work suffers terribly when I don't have my cup of coffee.
>
>
Odd. The information I came across stated something along the lines that buspar increased prozacs effects, possibly causing adverse reactions such as too much serotinin- I do agree that the combo with a TCA may be different.
Also interesting is that my depression was never one of sadness and deep crying tangents until I went on the buspar, which increased the crying/sadness, but stopped the 'anxiety shakes'. It seemed to open a floodgate or something- or maybe it's too many years on ad's, but I get the sadness and meloncoly (sp?)-and sometimes tearful episodes now when I try to go off the AD's, but still get a different kind of depression while ON the meds,too.
I also have that 'out of it' dissassociative sort of feeling at times, too.
Sometimes I don't know if my SSRI is making my depression worse- but when I go off I fall apart-and I've tried just about every AD there is, except MOAI's. And I can't tolerate noradrenergic ad's-I get too jittery.
Hildi


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