Posted by jrbecker on February 8, 2003, at 16:07:07
In reply to Re: Is there an updated list? » SLS, posted by Dave1 on February 8, 2003, at 15:34:22
Gepirone plays a role of selectivity for both the 5HT1a pre- and post-synaptic receptors. Unlike Buspar, it has a much higher affinity for this receptor over the D2 receptor. Long-term studies have shown that gepirone has a differential action at presynaptic (agonist) and post-synaptic (partial agonist) 5-HT1A receptors.
It can be argued that the 5HT1a postsynaptic receptor's role in anxiety in depression is probably the most important of all the serotonin subreceptors. It is believed that the delayed onset of most SSRI's might be due to the period of time it takes for the desensitzation of the 5HT1a recpetors to occur. The receptor has a very distinct role in decreasing worry, aggression, and depression. It also helps increase vigilance as well as libido. Thus, it might have a very important role for atypical depressives. Columbia University in NYC is currently holding a trial of gepirone for just such a purpose. If you suffer from atypical depression and are interested in the trial, please call their Depression Evaluation Service at 212-543-5734. The renowned Columbia team of Stewart, McGrath, and Quitkin are all involved with this study. I know for a fact that they are closing down admittance into this study in the next month or so though.JB
poster:jrbecker
thread:139984
URL: http://www.dr-bob.org/babble/20030208/msgs/140184.html